Adapting the Adaptor

Science's STKE  08 May 2007:
Vol. 2007, Issue 385, pp. tw161
DOI: 10.1126/stke.3852007tw161

Adaptor proteins connect the proteins involved in multiple cell signaling pathways. In T cells, the adaptor protein ADAP regulates certain signals from the T cell receptor (TCR) that influence the function of integrin adhesion receptors. Medeiros et al. found that ADAP also associates directly with another adaptor, CARMA1, a membrane-associated protein that couples TCR signaling to the activation of the core transcription factor NF-κB. This association involved the assembly of a multiprotein complex that failed to form in the absence of ADAP and corresponded with impaired NF-κB activity. The study introduces a key new step in regulating the pathway that connects TCR activation with the transcriptional response to infection.

R. B. Medeiros, B. J. Burbach, K. L. Mueller, R. Srivastava, J. J. Moon, S. Highfill, E. J. Peterson, Y. Shimizu, Regulation of NF-κB activation in T cells via association of the adapter proteins ADAP and CARMA1. Science 316, 754-758 (2007). [Abstract] [Full Text]