Cell Biology

IP4 Recruits Signaling Proteins

Science's STKE  15 May 2007:
Vol. 2007, Issue 386, pp. tw169
DOI: 10.1126/stke.3862007tw169

Inositol phosphates are important intracellular second messengers in eukaryotic cells. In particular, higher-order inositol polyphosphates regulate a range of biological processes, from chromatin remodeling to calcium signaling. Huang et al. (see the Perspective by Irvine) now report that inositol (1,3,4,5)-tetrakisphosphate (IP4) plays an unexpected role in T cells by modifying a well-established protein recruitment pathway. Soluble IP4 in the cell was found to lock onto plekstrin homology domains that regulate the recruitment of signaling proteins to the cell membrane for activation during T cell development.

Y. H. Huang, J. A. Grasis, A. T. Miller, R. Xu, S. Soonthornvacharin, A. H. Andreotti, C. D. Tsoukas, M. P. Cooke, K. Sauer, Positive regulation of Itk PH domain function by soluble IP4. Science 316, 886-889 (2007). [Abstract] [Full Text]

R. Irvine, The art of the soluble. Science 316, 845-846 (2007). [Summary] [Full Text]