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COVER This week's Focus Issue, published to complement the Science Special Issue on Single Molecules contains an Editorial Guide as well as three Perspectives that discuss technical advances that allow cell signaling researchers to zoom in on individual molecules. [Image: Christopher Bickel, AAAS]

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882