Foxp3 Is Required Throughout the Life of a Regulatory T Cell

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Science's STKE  03 Jul 2007:
Vol. 2007, Issue 393, pp. pe36
DOI: 10.1126/stke.3932007pe36

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The forkhead family transcription factor Foxp3 is critical for the development and function of CD4+CD25+ regulatory T cells (Tregs). A series of reports have begun to shed light on the precise role of Foxp3 in the regulation of the Treg transcriptome. Foxp3 can bind to specific gene elements, thereby altering transcription of target genes directly, and Foxp3 can alter the expression of genes encoding other transcription factors, thereby having an indirect effect on the transcription of target genes. Cells retaining aspects of Treg differentiation persist in the absence of Foxp3, which is suggestive of a Foxp3-independent aspect of Treg biology.

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