Growth Hormone and Development

Science's STKE  17 Jul 2007:
Vol. 2007, Issue 395, pp. tw256
DOI: 10.1126/stke.3952007tw256

During development, genes are often transcribed in a temporally and spatially regulated manner. The murine growth hormone gene is differentially expressed in the developing pituitary gland. Lunyak et al. now examine the region surrounding the growth hormone gene and show that a repeated DNA sequence (short interspersed nuclear element B2) in the growth hormone locus functions as an insulator to produce a boundary for chromatin domains and limit the action of regulatory factors such as enhancers and silencers.

V. V. Lunyak, G. G. Prefontaine, E. Núñez, T. Cramer, B.-G. Ju, K. A. Ohgi, K. Hutt, R. Roy, A. García-Díaz, X. Zhu, Y. Yung, L. Montoliu, C. K. Glass, M. G. Rosenfeld, Developmentally regulated activation of a SINE B2 repeat as a domain boundary in organogenesis. Science 317, 248-251 (2007). [Abstract] [Full Text]