Cohesin Does the Business

Science's STKE  17 Jul 2007:
Vol. 2007, Issue 395, pp. tw257
DOI: 10.1126/stke.3952007tw257

To ensure the sorting of a complete complement of chromosomes to both daughter cells in cell division, sister chromatids are bound together by a ring-shaped molecular complex called cohesin. The accurate repair of double-stranded lesions in DNA also relies on cohesion between homologous regions of sister chromatids. Both these processes are often misregulated in cancer. Cohesion has been thought to require ongoing DNA replication (see the Perspective by Watrin and Peters). Ünal et al. and Ström et al. now show in yeast that double-stranded breaks can induce cohesion in the absence of replication and that the deposition of cohesin is not limited to the region of the break but extends across the entire genome and, thus, may play a role in maintaining genome stability.

E. Watrin, J.-M. Peters, How and when the genome sticks together. Science 317, 209-210 (2007). [Summary] [Full Text]

E. Ünal, J. M. Heidinger-Pauli, D. Koshland, DNA double-strand breaks trigger genome-wide sister-chromatid cohesion through Eco1 (Ctf7). Science 317, 245-248 (2007). [Abstract] [Full Text]

L. Ström, C. Karlsson, H. B. Lindroos, S. Wedahl, Y. Katou, K. Shirahige, C. Sjögren, Postreplicative formation of cohesion is required for repair and induced by a single DNA break. Science 317, 242-245 (2007). [Abstract] [Full Text]