PerspectiveMOTILITY

Chemotaxis: Navigating by Multiple Signaling Pathways

STKE  24 Jul 2007:
Vol. 2007, Issue 396, pp. pe40
DOI: 10.1126/stke.3962007pe40

You are currently viewing the abstract.

View Full Text

Log in


Abstract

During chemotaxis, phosphatidylinositol 3,4,5-trisphosphate (PIP3) accumulates at the leading edge of a eukaryotic cell, where it induces the formation of pseudopodia. PIP3 has been suggested to be the compass of cells navigating in gradients of signaling molecules. Recent observations suggest that chemotaxis is more complex than previously anticipated. Complete inhibition of all PIP3 signaling has little effect, and alternative pathways have been identified. In addition, selective pseudopod growth and retraction are more important in directing cell movement than is the place where new pseudopodia are formed.

View Full Text