31 July 2007
Vol 2007, Issue 397
  • Contents

    • Perspective

    • Editors' Choice

      • An Arrestin Immune Response

        β-Arrestin-1 plays a key role in CD4+ T cell homeostasis by regulating the expression of Bcl-2.

      • BAK1 for Pathogen Response

        The leucine-rich repeat receptor-like kinase BAK1 interacts with pathogen-associated molecular pattern receptors to allow plants to respond to pathogens.

      • Sensing Cytosolic DNA

        DAI is a protein that triggers interferon gene expression and the innate immune response when cells are exposed to cytosolic DNA.

      • Twisted Signaling

        Crystal structures reveal how stem cell factor drives Kit receptor dimerization.

      • Essence of Alpha Male

        Neurogenesis in the olfactory bulb and hippocampus of female mice is stimulated by the odors of the alpha male, which helps the female select the best mate.

      • Sensor Evolution in Action

        Strains of photosynthetic bacteria use a nearly identical protein to sense light or oxygen concentrations.

      • Leukotriene Synthesis Inhibitors in a FLAP

        The structure of a human membrane protein involved in biosynthesis of the inflammation-related leukotrienes may help guide the development of therapeutics.

      • Noise, Gene Expression, and Competence

        Bacteria that show more random fluctuations in gene expression are especially likely to switch to an alternative phenotype in which they can take up foreign genetic material.

      • Correcting Cocaine-Induced Plasticity

        A decrease in the effectiveness of synapses in a particular brain region is caused by replacement of one glutamate receptor subtype with a less efficient one.

About The Cover

Cover image expansion

COVER This week features a Perspective on the role of molecular scaffolds in mediating crosstalk between different classes of seven-transmembrane receptors. The image depicts β-arrestin (PDB 1jsy).