Editors' ChoiceCell Biology

Insulin Signaling Up Close and Personal

Science's STKE  07 Aug 2007:
Vol. 2007, Issue 398, pp. tw284
DOI: 10.1126/stke.3982007tw284

Novel quantitative methods are allowing the analysis of gene and protein expression in unprecedented detail. Dong et al. (see the Perspective by Kim) profiled protein abundance changes in response to perturbations of insulin and insulin-like growth factor-1 (IGF-1) signaling in Caenorhabditis elegans and identified 86 targets. More than half of the targets identified by this quantitative proteomics approach were not previously identified and may provide new insights into the mechanisms of diabetes and aging.

M.-Q. Dong, J. D. Venable, N. Au, T. Xu, S. K. Park, D. Cociorva, J. R. Johnson, A. Dillin, J. R. Yates III, Quantitative mass spectrometry identifies insulin signaling targets in C. elegans. Science 317, 660-663 (2007). [Abstract] [Full Text]

S. K. Kim, Proteins that promote long life. Science 317, 603-604 (2007). [Summary] [Full Text]

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