ReviewStructural Biology

Structure and Function of the PB1 Domain, a Protein Interaction Module Conserved in Animals, Fungi, Amoebas, and Plants

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Science's STKE  28 Aug 2007:
Vol. 2007, Issue 401, pp. re6
DOI: 10.1126/stke.4012007re6

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With 9 figures, four interactive structure figures, and 170 citations, this Review describes the structure-function relationships of proteins with PB1 domains. Three types of PB1-containing proteins occur: those with a type I domain, those with a type II domain, and those with both type I and type II (type I/II). The type I domain mediates interactions with proteins containing a type II domain in a canonical PB1-PB1 interaction. Interactions mediated by PB1 domains are important for organizing cell structure, for example, in polarized cells (epithelial cells and neurons) and in skeletal muscle. In addition, interactions involving PB1 domains influence the activation of mitogen-activated protein kinase signaling and activation of NADPH oxidase.