18 September 2007
Vol 2007, Issue 404
  • Contents

    • Perspectives

    • Editors' Choice

      • Tailor-Made Toll-Like Receptor

        An innate immune receptor in humans selectively protects against severe infection of the central nervous system by herpes simplex virus 1.

      • Receptor Swapping

        Neutrophils put receptors borrowed from platelets to good use.

      • Regulating Glucose

        Glucose sensing by hypothalamic proopiomelanocortin neurons is implicated in systemic glucose homeostasis and lost in obese mice fed a high-fat diet.

      • Establishing Asymmetry

        The microRNAs miR-15 and miR-16 link asymmetry in Wnt/β-catenin to asymmetry in Nodal signaling and thereby play a crucial role in regulating embryonic patterning.

      • Preventing Transformation

        Organized epithelial structures resist transformation through a mechanism involving LKB1.

      • Functional Evolution of Proteins

        The structure of a 450-million-year-old corticoid receptor, resurrected computationally and biochemically, suggests how modern hormone receptors evolved.

About The Cover

Cover image expansion

COVER This week features a Perspective on regulation of nitric oxide synthase by β-actin. The image depicts a single monomer of β-actin. [Image based on PDB 2oan]