25 September 2007
Vol 2007, Issue 405
  • Contents

    • Perspectives

    • Editors' Choice

      • Opposing Signals Working Together

        The calcium increase at fertilization independently activates kinase and phosphatase activity.

      • Control of a Metamorphic Switch

        A microRNA-mediated feedback loop contributes to regulation of insect metamorphosis.

      • Sensing Sugar in the Gut

        Taste receptors appear to play a role in sensing sugar in the intestinal tract.

      • Tag Team

        A family of ubiquitin ligases targets SUMOylated proteins.

      • Gating ASICs

        Acid-sensing ion channels exist as trimers that may be gated through movement of an extracellular "thumb."

      • Transporting Zinc

        The crystal structure of a bacterial membrane transporter reveals that it uses an unusual two-site, zinc-for-proton exchange mechanism.

      • Solution Interactions via Interferometry

        Free-solution, label-free molecular interactions can be investigated using back-scattering interferometry (BSI), which allows quantification of Kd values ranging from micromolar to picomolar using minuscule quantities of the binding pairs.

      • Moving Through an Electrical Field

        Metastatic cells appear to use the epidermal growth factor receptor ErbB1 to migrate through an electric field.

About The Cover

Cover image expansion

COVER This week features a Perspective on variant IFN-α proteins with distinct activities. The image depicts human IFN-α. [Image based on PDB 1rh2.]