One of the classic problems in embryology is the segmentation of the body plan. In vertebrates, this process is underpinned by a multicellular oscillatory genetic network. Riedel-Kruse et al. modeled this complex "segmentation clock" as a population of simple, coupled oscillators in the presence of noise and compared their modeling with experimentally induced segment defects after quantitative inhibition of Notch signaling in the zebrafish embryo. The model predicts the position of posterior defects, a synchronized transition, and the existence of resynchronization and allows the estimation of coupling strength, noise, and robustness to perturbation.
- Modeling Developmental Segmentation
A model of the segmentation clock, coupled genetic oscillators that sequentially generate the body segments of animals, successfully predicts the results of system perturbations.Permalink: