Editors' ChoiceNeuroscience

Neuronal Pathfinding

STKE  02 Oct 2007:
Vol. 2007, Issue 406, pp. tw356
DOI: 10.1126/stke.4062007tw356

During development, the growing tips of neurons must locate and identify their preferred targets. Neurons follow attractive and repulsive guidance signals to build a network to connect muscle activity to brain signals, sensory inputs to behavioral responses, and so on. Fujisawa et al. have now discovered another component, EVA-1, in the guidance system for neurons that fine-tunes the guidance signals sent and received by different neurons in the model organism Caenorhabditis elegans.

K. Fujisawa, J. L. Wrana, J. G. Culotti, The Slit receptor EVA-1 coactivates a SAX-3/Robo–mediated guidance signal in C. elegans. Science 317, 1934-1938 (2007). [Abstract] [Full Text]