09 October 2007
Vol 2007, Issue 407
  • Contents

    • Editorial Guide

    • Editors' Choice

      • How Clocks See the Light

        Hydrogen peroxide functions in entrainment of the zebrafish circadian clock in response to light.

      • Harming Thyself

        An antimicrobial peptide, LL37, complexes with self-DNA to trigger interferon-α production by plasmacytoid dendritic cells.

      • Released from the Nucleolus

        Phosphorylation of the transcription factor Hand1 releases it from the nucleolus, allowing cell differentiation.

      • Keeping p53 in the Nucleus

        Poly(ADP-ribosyl)ation of p53 in response to DNA damage prevents its interaction with the nuclear export receptor.

      • Learning, Autism, and the Synapse

        A mouse model reveals that a mutation that changes the balance of excitatory and inhibitory synapses affects learning skills, a finding that may help in understanding autism.

      • Neuronal Road Map

        Glial cells can orchestrate neuron-to-neuron connections by attracting processes from the postsynaptic cell and triggering synapse formation in the presynaptic cell.

      • Plant Protector Identified

        In response to viral infection, tobacco plants locally produce methyl salicylate, which then spreads and renders the whole plant more resistant to subsequent infections.

      • The Silence of the Flowering Genes

        Two proteins known to participate in flowering are also required for chromatin silencing at various genetic loci early in Arabidopsis development.

    • Connections Map Overviews

About The Cover

Cover image expansion

COVER This week's Focus Issue, published in conjunction with the Science Special Collection on Cell Signaling, features 7 new or updated pathways in the Database of Cell Signaling, which are also briefly highlighted in the associated Editorial Guide. The image depicts an "insider's view" of cell signaling. [Image: Christopher Bickel, AAAS]