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Hedgehog Signaling Pathway

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Science's STKE  09 Oct 2007:
Vol. 2007, Issue 407, pp. cm6
DOI: 10.1126/stke.4072007cm6

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The Hedgehog (Hh) signaling pathway is essential for development and tissue homeostasis in metazoans. Probably as a result of its potent influence on cell-fate outcomes, the Hh pathway when corrupted results in malformations and diseases such as cancer. Many of the pathway components that contribute to Hh-mediated signal transduction are presented.

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