PerspectiveIon Channels

Alchemy in the Soup: Transforming Metabolic Signals to Excitability

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Science's STKE  30 Oct 2007:
Vol. 2007, Issue 410, pp. pe59
DOI: 10.1126/stke.4102007pe59

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The intersection of cell metabolism with electrical signaling links the environment and cell function over time scales ranging from milliseconds to lifetimes. In responding to cellular metabolites, adenosine triphosphate (ATP)–sensitive potassium (KATP) channels are an important component of this intersection. Recent studies have begun to delineate the roles of KATP channels in multiple tissues and the far-reaching consequences of aberrant KATP channel activity and disturbed sensing of cell metabolism.

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