Editors' ChoiceCell Biology

Life and Death Decisions

Science's STKE  13 Nov 2007:
Vol. 2007, Issue 412, pp. tw412
DOI: 10.1126/stke.4122007tw412

How do cells determine whether to live or die after exposure to stressors that cause misfolding of intracellular proteins? Lin et al. find that the IRE1 signaling branch of the unfolded protein response plays a key role in promoting cell survival after protein misfolding in the endoplasmic reticulum (ER). Human cells shut off IRE1 signaling after prolonged ER protein misfolding in order to enhance cell survival.

J. H. Lin, H. Li, D. Yasumura, H. R. Cohen, C. Zhang, B. Panning, K. M. Shokat, M. M. LaVail, P. Walter, IRE1 signaling affects cell fate during the unfolded protein response. Science 318, 944-949 (2007). [Abstract] [Full Text]

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