PerspectiveNeuronal Polarity

Putting on the RITz

+ See all authors and affiliations

Science's STKE  11 Dec 2007:
Vol. 2007, Issue 416, pp. pe71
DOI: 10.1126/stke.4162007pe71

You are currently viewing the abstract.

View Full Text


Neurons develop two types of processes, axons and dendrites, whose growth must be independently controlled. Recent research has identified the small guanosine triphosphatase Rit as a differential regulator of neurite growth. Activation of Rit enhances axonal growth, whereas inhibition of Rit promotes dendritic growth. These results imply that the reciprocal regulation of a single molecule in the same cell can achieve simultaneous regulation of axonal and dendritic growth.

View Full Text