PerspectiveNeuronal Polarity

Putting on the RITz

Science's STKE  11 Dec 2007:
Vol. 2007, Issue 416, pp. pe71
DOI: 10.1126/stke.4162007pe71

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Neurons develop two types of processes, axons and dendrites, whose growth must be independently controlled. Recent research has identified the small guanosine triphosphatase Rit as a differential regulator of neurite growth. Activation of Rit enhances axonal growth, whereas inhibition of Rit promotes dendritic growth. These results imply that the reciprocal regulation of a single molecule in the same cell can achieve simultaneous regulation of axonal and dendritic growth.

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