PerspectiveCell Biology

Cyclic Nucleotides Converge on Brown Adipose Tissue Differentiation

+ See all authors and affiliations

Sci. Signal.  12 Jan 2010:
Vol. 3, Issue 104, pp. pe2
DOI: 10.1126/scisignal.3104pe2

You are currently viewing the abstract.

View Full Text


Brown adipose tissue (BAT) is rich in mitochondria and can uncouple oxidative phosphorylation to produce heat as a by-product of fatty acid metabolism. This thermogenic effect helps to maintain body temperature and also plays a critical role in energy homeostasis and the regulation of body weight. Both cyclic adenosine monophosphate and cyclic guanosine monophosphate (cGMP) contribute to the intracellular regulation of mitochondrial biogenesis and the differentiation of BAT. New evidence has defined the essential role of the cGMP-dependent protein kinase I in a pathway that modulates the RhoA-ROCK pathway and insulin receptor signaling to elicit BAT differentiation and stimulate thermogenesis.

View Full Text