Basal Release of ATP: An Autocrine-Paracrine Mechanism for Cell Regulation

Sci. Signal., 12 January 2010
Vol. 3, Issue 104, p. re1
DOI: 10.1126/scisignal.3104re1

Basal Release of ATP: An Autocrine-Paracrine Mechanism for Cell Regulation

  1. Ross Corriden and
  2. Paul A. Insel*
  1. Departments of Pharmacology and Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
  1. *Corresponding author. E-mail, pinsel{at}


Cells release adenosine triphosphate (ATP), which activates plasma membrane–localized P2X and P2Y receptors and thereby modulates cellular function in an autocrine or paracrine manner. Release of ATP and the subsequent activation of P2 receptors help establish the basal level of activation (sometimes termed "the set point") for signal transduction pathways and regulate a wide array of responses that include tissue blood flow, ion transport, cell volume regulation, neuronal signaling, and host-pathogen interactions. Basal release and autocrine or paracrine responses to ATP are multifunctional, evolutionarily conserved, and provide an economical means for the modulation of cell, tissue, and organismal biology.


R. Corriden and P. A. Insel, Basal Release of ATP: An Autocrine-Paracrine Mechanism for Cell Regulation. Sci. Signal. 3, re1 (2010).

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