Editors' ChoiceCell Biology

Integrin G Protein

Sci. Signal.  19 Jan 2010:
Vol. 3, Issue 105, pp. ec19
DOI: 10.1126/scisignal.3105ec19

Adhesion molecules known as integrins are found on the surface of cells. When integrins adhere to components of the extracellular matrix, they act as receptors and initiate signaling events within the cell. Gong et al. show that they do so in part by partnering with a signal-transducing protein called Gα13. Such alpha subunits of heterotrimeric guanine nucleotide–binding proteins are well known for transducing signals from the large class of G protein–coupled receptors but were not known to work with integrins, a different class of receptor. Gα13 appears to interact directly with the integrin αIIbβ3 and to transmit signals that regulate cell spreading.

H. Gong, B. Shen, P. Flevaris, C. Chow, S. C.-T. Lam, T. A. Voyno-Yasenetskaya, T. Kozasa, X. Du, G protein subunit Gα13 binds to integrin αIIbβ3 and mediates integrin “outside-in” signaling. Science 327, 340–343 (2010). [Abstract] [Full Text]

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