ReviewDendritic Cells

What Is the Function of the Dendritic Cell Side of the Immunological Synapse?

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Sci. Signal.  19 Jan 2010:
Vol. 3, Issue 105, pp. re2
DOI: 10.1126/scisignal.3105re2

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The immune response requires the formation of a specialized interface called the immunological synapse (IS), which is formed between a mature dendritic cell (DC) and a CD4+ T cell in the lymph node. The IS consists of organized motifs formed by cell-surface and cytoplasmic molecules at both the DC side and the T cell side of the IS, herein called IS-DC and IS-T, respectively. Most studies of the IS have focused on the IS-T. In this Review, which contains two figures, one table, and 76 citations, we discuss findings that show that the IS-DC also contributes to the regulation of functions that could be important for the immune response.