ReviewDendritic Cells

What Is the Function of the Dendritic Cell Side of the Immunological Synapse?

Sci. Signal.  19 Jan 2010:
Vol. 3, Issue 105, pp. re2
DOI: 10.1126/scisignal.3105re2

You are currently viewing the gloss.

View Full Text

Via your Institution

Log in through your institution

Log in through your institution


Gloss

The immune response requires the formation of a specialized interface called the immunological synapse (IS), which is formed between a mature dendritic cell (DC) and a CD4+ T cell in the lymph node. The IS consists of organized motifs formed by cell-surface and cytoplasmic molecules at both the DC side and the T cell side of the IS, herein called IS-DC and IS-T, respectively. Most studies of the IS have focused on the IS-T. In this Review, which contains two figures, one table, and 76 citations, we discuss findings that show that the IS-DC also contributes to the regulation of functions that could be important for the immune response.

Related Content