Contents
Vol 3, Issue 113
Contents
Research Articles
- Cholinergic Augmentation of Insulin Release Requires Ankyrin-B
The scaffolding protein ankyrin-B is needed for maximal insulin release, and loss of function is a risk factor for diabetes.
- Inferring Signaling Pathway Topologies from Multiple Perturbation Measurements of Specific Biochemical Species
Bayesian inference–based modeling identifies the most likely paths through a signaling network.
- A Loss-of-Function Screen Reveals Ras- and Raf-Independent MEK-ERK Signaling During Chlamydia trachomatis Infection
An siRNA-based screen of host factors that influence infection by Chlamydia reveals the decoupling of the canonical Ras-ERK signaling pathway.
Podcast
- Science Signaling Podcast: 16 March 2010
Reduction of ankyrin-B activity impairs maximal insulin release and is a risk factor for diabetes.
Editors' Choice
- Immune Complications of Ablation Therapy
B cells recruited by dying prostate cancer cells trigger the development of androgen-resistant tumor cells.
- Ido for Lowering Blood Pressure
Tryptophan metabolism to kynurenine represents a previously unknown pathway for regulation of blood pressure during systemic inflammation.
- Death Transferred
The interaction between cytochrome c and Apaf-1 is blocked by tRNA, thus inhibiting the activation of caspases.
- Signaling by Diffusion
Actin and ezrin networks limit signaling through the BCR by restricting its mobility.
- Moving Signals
Mechanical forces acting on a cell-surface receptor affect the activation of a signaling pathway involved in breast cancer.
- Thalidomide Target Identified
Thalidomide binding to a component of an E3 ubiquitin ligase induces developmental defects in vertebrates.
- Building Muscle Is a Pain
Bradykinin released during exercise stimulates nerve growth factor production by muscle, which sensitizes pain nerves and leads to delayed muscle soreness.
- Steady As She Blows
Models of metabolic regulation show how the stability of specific components is maintained within a varying environment.
