ReviewCell death

The Role of the Kinases RIP1 and RIP3 in TNF-Induced Necrosis

Science Signaling  30 Mar 2010:
Vol. 3, Issue 115, pp. re4
DOI: 10.1126/scisignal.3115re4

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  1. Article
    1. Abstract
    2. TNF, a Pleiotropic Molecule
    3. Apoptosis and Necrosis, Two Sides of the Same Coin
    4. Distinct TNF Complexes Determine the Signaling Mode
    5. RIP1 and RIP3, the Danse Macabre of Two Kinases Leading to Necrosis
    6. Which Signaling Pathways are Downstream of the RIP1 and RIP3 Signaling Complex in TNF-Induced Necrosis?
    7. In Vivo Role of RIP1- and RIP3-Mediated Necrosis in Pathophysiology
    8. Perspectives
    9. Acknowledgments
    10. References and Notes
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