A Trojan Horse for Parkinson’s Disease

Sci. Signal., 6 April 2010
Vol. 3, Issue 116, p. pe13
DOI: 10.1126/scisignal.3116pe13

A Trojan Horse for Parkinson’s Disease

  1. Yi Hu* and
  2. Youren Tong
  1. Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, 65 Landsdowne Street, Cambridge, MA 02139, USA.
  1. *Corresponding author. E-mail: yi_hu{at}hms.harvard.edu

Abstract

Pathogenic mutations in leucine-rich repeat kinase 2 (LRRK2) are common genetic causes of late-onset Parkinson’s disease (PD). Initial studies indicated that the intrinsic kinase activity of LRRK2 is associated with LRRK2-mediated PD pathogenesis. However, LRRK2 kinase activity may be dispensable for neuron survival and may not be required for its protective activity against neurotoxicity. Thus, the intrinsic kinase activity of LRRK2 appears to be a Trojan horse for PD, and inhibition of its kinase activity could potentially be therapeutically beneficial.

Citation:

Y. Hu and Y. Tong, A Trojan Horse for Parkinson’s Disease. Sci. Signal. 3, pe13 (2010).
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