20 April 2010
Vol 3, Issue 118

About The Cover

Cover image expansion

Online Cover This week's issue features a Research Article describing an example of the effectiveness of systems pharmacology in linking drug targets and disease genes through protein interaction networks, which is a step toward personalized medicine and safer drug prescribing. By integrating protein interaction data with data about the genetics underlying the cardiac disease long QT syndrome (LQTS), Berger et al. identified a network associated with this potentially fatal cardiac disorder. By combining this LQTS network with data about adverse effects of drugs, they identified drugs that may induce LQTS. The image shows an electrocardiogram trace represented by alternating drugs and chromosomes. [Image: Seth I. Berger, Ravi Iyengar, Department of Pharmacology and Systems Therapeutics and Systems Biology Center New York, Mount Sinai School of Medicine, NY]