Research ArticlePharmacology

Systems Pharmacology of Arrhythmias

Science Signaling  20 Apr 2010:
Vol. 3, Issue 118, pp. ra30
DOI: 10.1126/scisignal.2000723

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Arrhythmic Neighborhood

By integrating protein interaction data with data about the genetics underlying disease, Berger et al. identified a network associated with a specific disease, long QT syndrome (LQTS). This particular, potentially fatal, cardiac disorder can also be caused by various drugs, both those used to treat cardiovascular disease and those used to treat non–cardiac-related conditions. By combining this LQTS network with other genomic data sets, Berger et al. identified genetic variations likely to influence a person’s susceptibility to LQTS. By combining this LQTS network with data about adverse effects of drugs, they identified drugs that may induce LQTS. This provides an example of the effectiveness of systems pharmacology in linking drug targets and disease genes through protein interaction networks, which is a step toward personalized medicine and safer drug prescribing.