By Kristin K. Jernigan, Christopher S. Cselenyi, Curtis A. Thorne, Alison J. Hanson, Emilios Tahinci, Nicole Hajicek, William M. Oldham, Laura A. Lee, Heidi E. Hamm, John R. Hepler, Tohru Kozasa, Maurine E. Linder, Ethan Lee
Sci. Signal. : ra37 Full AccessRestricted Access
A Xenopus reconstitution system reveals that the G protein Gβγ subunit contributes to β-catenin stabilization.
Online Cover This week's issue features a Research Article that shows that intracellular vesicles containing the transmembrane adaptor protein LAT migrate to and interact with protein microclusters at the interface between a T cell and an antigen-presenting cell. The image shows vesicular LAT (red) and microclusters containing the T cell receptor–associated kinase ZAP-70 (green) at the interface between a Jurkat T cell and a coverslip coated with an activating antibody. [Image: Marco Purbhoo, Imperial College London, UK]