Making Menorahs

Science Signaling  08 Jun 2010:
Vol. 3, Issue 125, pp. ec176
DOI: 10.1126/scisignal.3125ec176

Highly branched neuronal processes are typical of numerous neurons. The mechanisms controlling the formation, maintenance, and regeneration of neuronal trees are poorly understood. Oren-Suissa et al. observed the development of extensively arborized neurite trees—menorahs—in two highly branched mechanosensory neurons in Caenorhabditis elegans. EFF-1, a fusion protein known to be important for cell fusion, played a key role in arborization.

M. Oren-Suissa, D. H. Hall, M. Treinin, G. Shemer, B. Podbilewicz, The fusogen EFF-1 controls sculpting of mechanosensory dendrites. Science 328, 1285–1288 (2010). [Abstract] [Full Text]