Host-Pathogen Interactions

Bacterial (Interferon)ce

Science Signaling  29 Jun 2010:
Vol. 3, Issue 128, pp. ec200
DOI: 10.1126/scisignal.3128ec200

Intracellular bacterial pathogens, such as Listeria monocytogenes, are detected in the cytosol of host immune cells, where they induce a host response that is often dependent on microbial secretion systems. Woodward et al. now show that L. monocytogenes produces and releases cyclic diadenosine monophosphate (c-di-AMP) into the host cytosol, which induces the production of host type I interferon. Because a number of intracellular pathogens contain the protein machinery to generate this nucleotide and also activate this same innate immune pathway, a common molecular mechanism may exist for host detection of cytosolic bacterial pathogens.

J. J. Woodward, A. T. Iavarone, D. A. Portnoy, c-di-AMP secreted by intracellular Listeria monocytogenes activates a host type I interferon response. Science 328, 1703–1705 (2010). [Abstract] [Full Text]