13 July 2010
Vol 3, Issue 130
  • Contents

    • Research Articles

    • Editors' Choice

      • Pricking Out Pain with Adenosine

        By stimulating the production of adenosine, acupuncture stimulates a class of pain-relieving receptors in the periphery.

      • Organized Randomness

        The self-organization of phosphatidylinositol lipids along the membranes of Dictyostelium cells enables spontaneous cell migration.

      • Correcting a Liver Problem

        A mouse model of a human liver disease can be treated using a drug known to be well tolerated.

      • Radical Autonomic Insufficiency

        Diabetic sympathetic dysfunction may result from an adaptive response to excess circulating glucose.

      • Stuck on You

        Cleavage of the zona pellucida component ZP2 is required to prevent sperm binding to fertilized eggs.

      • BK Channel Cytoplasmic Domain

        A tetramer of two regulatory domains forms a gating ring that regulates calcium ion activation.

      • Righting Repair Pathways

        A specific pathway protects damaged DNA from error-prone repair.

About The Cover

Cover image expansion

Online Cover This week features a Research Article describing the phosphoproteomic signals and transcriptional changes that allow an injured neuron to switch from a "growth as normal" mode to an "injury response" mode. Michaelevski et al. combined phosphoproteomic analyses of injured and uninjured rat sciatic nerve with microarray analyses of transcripts in the dorsal root ganglia to identify retrograde signaling networks implicated in activating the transcriptional response to axonal injury. The image shows a dorsal root ganglion responding to a distal injury. [Image: Yana Greenman, AAAS]