LetterAntibodies

Response to Comment on “Increased MKK4 Abundance with Replicative Senescence Is Linked to the Joint Reduction of Multiple MicroRNAs”

Science Signaling  20 Jul 2010:
Vol. 3, Issue 131, pp. lc2
DOI: 10.1126/scisignal.3131lc2

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Abstract

Moens and colleagues express concern that our report of phosphorylation of p38–regulated/activated protein kinase (PRAK) at Ser93 in senescent cells may be incorrect as a result of their inability to detect phosphorylated PRAK with the same antibody. We provide additional characterization of the antibody that we used and show that there is a 42-kilodalton phosphoprotein detected by this antibody, but that this phosphoprotein may not be PRAK.

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