Research ArticleCOMPUTATIONAL BIOLOGY

Decoupling of Receptor and Downstream Signals in the Akt Pathway by Its Low-Pass Filter Characteristics

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Sci. Signal.  27 Jul 2010:
Vol. 3, Issue 132, pp. ra56
DOI: 10.1126/scisignal.2000810

Article Information

vol. 3 no. 132 ra56

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History: 
  • Received December 28, 2009
  • Accepted July 9, 2010

Author Information

  1. Kazuhiro A. Fujita1,
  2. Yu Toyoshima2,
  3. Shinsuke Uda2,
  4. Yu-ichi Ozaki2,
  5. Hiroyuki Kubota2, and
  6. Shinya Kuroda1,2,*
  1. 1Department of Computational Biology, Graduate School of Frontier Sciences, University of Tokyo, Kshiwanoha 5-1-5, Kashiwa, Chiba 277-8568, Japan.
  2. 2Department of Biophysics and Biochemistry, Graduate School of Science, CREST, Japan Science and Technology Agency, University of Tokyo, Hongo 7-3-1, Bunkyo-ku,Tokyo 113-0033, Japan.
  1. *To whom correspondence should be addressed. E-mail: skuroda{at}bi.s.u-tokyo.ac.jp

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