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Online Cover This week's issue features a Perspective describing how three proteins—an orphan glutamate receptor on the postsynaptic side, a cell adhesion protein on the presynaptic side, and a secreted soluble factor—act as a transsynaptic bridge at a major type of cerebellar synapse. [Image: Yana Hammond]

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882