Cell Migration

Line Up for Movement

Science Signaling  24 Aug 2010:
Vol. 3, Issue 136, pp. ec261
DOI: 10.1126/scisignal.3136ec261

The nuclei of animal cells can move to specific locations and help to polarize migrating and differentiating cells. Luxton et al. (see the Perspective by Starr) found that linear arrays of nuclear membrane proteins assembled on, and moved with, actin cables toward the rear of the cell during nuclear movement in polarizing fibroblasts. Interfering with the components of these linear arrays prevented nuclear movement and centrosome reorientation. Thus, nuclear membrane proteins assemble into actin-dependent arrays during force transduction.

G. W. G. Luxton, E. R. Gomes, E. S. Folker, E. Vintinner, G. G. Gundersen, Linear arrays of nuclear envelope proteins harness retrograde actin flow for nuclear movement. Science 329, 956–959 (2010). [Abstract] [Full Text]

D. A. Starr, Nuclei get TAN lines. Science 329, 909–910 (2010). [Summary] [Full Text]