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Online Cover This week, Science Signaling features a Focus Issue that highlights protein phosphorylation, a central process in signal transduction pathways. The image shows representatives of two sides of the phosphorylation coin, with a crystal structure of the kinase domain of one isoform of protein kinase C (blue; PDB 3A8W) and a structure of the catalytic subunit of the protein phosphatase PP1 (green; PDB 1S70). [Image: Chris Bickel, AAAS]

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882