Research ResourceProtein Phosphorylation

Collection and Motif-Based Prediction of Phosphorylation Sites in Human Viruses

Science Signaling  31 Aug 2010:
Vol. 3, Issue 137, pp. rs2
DOI: 10.1126/scisignal.2001099

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Predictors of Phosphorylation

Viruses use, and abuse, the protein phosphorylation systems of infected cells to enhance their replication and to inhibit the responses of the host, among other processes. Thus, knowledge of the viral proteins that are regulated by phosphorylation, and of the sites that are modified, would improve our understanding of virus-host interactions and the development of therapeutic strategies to combat viral infection. Schwartz and Church have compiled the first online database of viral phosphorylation sites, virPTM, which they collected from published data on the phosphorylation of proteins from more than 50 viruses that infect humans. Further, the authors used the scan-x tool to make predictions about other possible phosphorylation sites, which have yet to be experimentally verified. Future additions to the database include information on other posttranslational modifications of viral proteins.