PerspectiveBook Review

NF-κB: Much Learned, Much to Learn

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Sci. Signal.  07 Sep 2010:
Vol. 3, Issue 138, pp. pe29
DOI: 10.1126/scisignal.3138pe29

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Although NF-κB (nuclear factor κB) was discovered less than 25 years ago, it is one of the most well-studied transcription factors. It plays critical roles in various immune and cellular processes, and its dysregulation is a major driver of cancer and inflammatory pathology. A new book published by Cold Spring Harbor Laboratory Press, NF-κB: A Network Hub Controlling Immunity, Inflammation, and Cancer, provides a series of excellent reviews on the architecture, regulation, and pathophysiological roles of NF-κB signaling by some of the leading investigators in the field.

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