Editors' ChoiceDNA Repair

UnSIRT6ain Repair

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Science Signaling  14 Sep 2010:
Vol. 3, Issue 139, pp. ec284
DOI: 10.1126/scisignal.3139ec284

Efficient and accurate repair of double-strand DNA breaks is critical for genome stability and involves a process known as homologous recombination. During repair of the sheared ends, the DNA must be resected by trimming one of the two strands on either side of the break. For the repair to be accurate, the remaining single-stranded DNA (ssDNA) has to be bound by the ssDNA-binding protein, RPA, after which the ssDNA can then bind homologous sequences. Kaidi et al. found that the mammalian deacetylase, SIRT6 (which has been implicated in maintaining genome stability), was critical for resection. At sites of DNA damage, SIRT6 deacetylated and activated CtIP (a protein important for resection), ensuring that resection occurred at the appropriate place and time.

A. Kaidi, B. T. Weinert, C. Choudhary, S. P. Jackson, Human SIRT6 promotes DNA end resection through CtIP deacetylation. Science 329, 1348–1353 (2010). [Abstract] [Full Text]