21 September 2010
Vol 3, Issue 140
  • Contents

    • Research Articles

    • Perspective

    • Editors' Choice

      • Going Outside When It’s Warm

        Changes in membrane thickness enable the bacterial histidine kinase DesK to act as a temperature sensor.

      • Drawn In by the Activity

        Increased neuronal activity promotes the uptake of IGF-1 by the brain from the circulation.

      • Glucose Metabolism Revisited

        Characterization of cancer cell metabolism provides evidence for a previously uncharacterized metabolic pathway.

      • Making Modifications

        The translational speed of proteins influences whether they are cotranslationally degraded after arginylation.

      • Complement for Inflammation Resolution

        Compromised T cell response to the complement system may contribute to chronic inflammatory diseases, such as rheumatoid arthritis.

      • Location Matters

        Compartmentalization of signaling components allows induction of distinct pathways downstream of a pathogen receptor.

      • MicroRNA-16 and Depression

        The uptake transporter for a key neurotransmitter is regulated by a microRNA, yielding new insight into how Prozac functions.

About The Cover

Cover image expansion

Online Cover This week features a Research Article that describes a network-centered approach for development of rationally designed combination therapies. The image is an artist's concept of a multidrug therapy kit. [Image: Chris Bickel, AAAS]