Nuclear Emancipation: A Platelet Tour de Force

Sci. Signal., 19 October 2010
Vol. 3, Issue 144, p. pe37
DOI: 10.1126/scisignal.3144pe37

Nuclear Emancipation: A Platelet Tour de Force

  1. Sherry L. Spinelli1,
  2. Sanjay B. Maggirwar2,
  3. Neil Blumberg1, and
  4. Richard P. Phipps1,2,3,*
  1. 1Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA.
  2. 2Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA.
  3. 3Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA.
  1. *Corresponding author: Department of Environmental Medicine, Box 850, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, USA. Telephone, 585-275-8326; fax, 585-276-0239; e-mail, richard_phipps{at}urmc.rochester.edu

Abstract

Mammalian platelets are anucleate cells produced by the polyploid megakaryocyte. Platelets are more than just key players in hemostasis (blood clotting in response to injury); they also have important roles in inflammation, immunity, tumor progression, and thrombosis. Complex systems of homeostasis have been described for platelets, including posttranscriptional and translational mechanisms to regulate platelet function. Platelets contain transcription factors, and these proteins have essential roles in regulating nongenomic processes. A study provides evidence for a previously unknown negative feedback pathway for limiting platelet activation that occurs through the nuclear factor κB transcription factor family. This pathway is mediated by an adenosine 3',5'-monophosphate–independent protein kinase A activity in response to platelet stimulation. Our appreciation of the role of transcription factors in mammalian platelet biology is nascent but holds great promise for both understanding platelet function and translation into clinical uses.

Citation:

S. L. Spinelli, S. B. Maggirwar, N. Blumberg, and R. P. Phipps, Nuclear Emancipation: A Platelet Tour de Force. Sci. Signal. 3, pe37 (2010).

Reply to Schattner
M. T. Rondina, A. S. Weyrich, and G. A. Zimmerman
Circ. Res. 113, e93-e93 (12 October 2013)

Role of NF-{kappa}B Pathway on Platelet Activation
M. Schattner, A. S. Weyrich, and G. A. Zimmerman
Circ. Res. 113, e92-e92 (12 October 2013)

Platelets as Cellular Effectors of Inflammation in Vascular Diseases
M. T. Rondina, A. S. Weyrich, and G. A. Zimmerman
Circ. Res. 112, 1506-1519 (24 May 2013)

A Sticky Story for Signal Transducer and Activator of Transcription 3 in Platelets
K. Chen, M. T. Rondina, and A. S. Weyrich
Circulation 127, 421-423 (29 January 2013)

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