Contents
Vol 3, Issue 146
Contents
Editorial Guide
- Focus Issue: Signals for Gene Expression
Signaling pathways can regulate gene expression—and vice versa.
Research Articles
- Rewiring of Transcriptional Regulatory Networks: Hierarchy, Rather Than Connectivity, Better Reflects the Importance of Regulators
Transcriptional regulatory networks appear to have an organization similar to a corporation, with top-level managers having the most influence.
- DNMT1 Stability Is Regulated by Proteins Coordinating Deubiquitination and Acetylation-Driven Ubiquitination
Degradation of a DNA methyltransferase implicated in cancer is determined by its acetylation status.
Perspectives
- Posttranscriptional Regulation of PTEN Dosage by Noncoding RNAs
The abundance of the tumor suppressor PTEN is modulated by microRNAs and pseudogenes.
- Intracellular Delivery Strategies for MicroRNAs and Potential Therapies for Human Cardiovascular Diseases
MicroRNAs can help maintain healthy cardiovascular systems or contribute to the pathogenesis of cardiovascular diseases.
Review
- Fibroblast Growth Factor Receptor Signaling Crosstalk in Skeletogenesis
Crosstalk of fibroblast growth factor signaling with other pathways may offer therapeutic strategies for skeletal dysplasias.
Editors' Choice
- Eau de Rotting Fruit
The Solomon’s lily targets odorant receptors that enable drosophilids to detect odors from their food source.
- A Fas2 Track down the Axon
Glial migration in the fly peripheral nervous system depends on an axonal gradient of Fasciclin2.
- The Inside Scoop on Toll
The early endosome, rather than the cell membrane, appears to be the critical location of signaling by the developmental morphogen receptor Toll in Drosophila.
- Multifarious Meristem Maintenance
A mutant screen identifies a third pathway through which CLAVATA3 regulates stem cell proliferation.
- Controlling Chloride Channels
The structure of a chloride transporter and its regulatory domain provides insight into the ion-exchange mechanism.
- Innate Innit?
Immune cells develop to preempt intestinal colonization by microbial symbionts.
