Journal ClubNeuroscience

Grooming and Growing with Microglia

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Sci. Signal.  09 Nov 2010:
Vol. 3, Issue 147, pp. jc8
DOI: 10.1126/scisignal.3147jc8

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Microglia mediate neuroprotection and neuropathogenesis but have not been directly associated with behavior. As gatekeepers of the brain’s immune system, microglia protect the brain from pathogens but also contribute to inflammation, which may negatively affect neurons. A recent study demonstrates a role for Hoxb8-expressing microglia in modulating behavior, a finding that is interesting from both the pathology and developmental biology perspectives.

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