PerspectiveCell Biology

Frizzled Signaling: Gαo and Rab5 at the Crossroads of the Canonical and PCP Pathways?

Sci. Signal.  16 Nov 2010:
Vol. 3, Issue 148, pp. pe43
DOI: 10.1126/scisignal.3148pe43

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Endocytosis modulates the activities of members of a family of receptors known as Frizzled (Fz) proteins, which control canonical β-catenin signaling and the planar cell polarity pathway; however, what determines which of the two pathways is activated is unclear. Evidence now suggests that the guanosine triphosphatase Rab5, a key regulator of endocytosis, binds directly to Fz proteins and that subsequent trafficking steps determine the outcome of Fz signaling.

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