Science Signaling Podcast: 23 November 2010

Science Signaling  23 Nov 2010:
Vol. 3, Issue 149, pp. pc21
DOI: 10.1126/scisignal.3149pc21

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This is a conversation with Elaine Reed about a Research Article published in the 23 November 2010 issue of Science Signaling. Zhang and colleagues report that human leukocyte antigen I (HLA-I) partners with the integrin β4 subunit to induce migration and proliferation of endothelial cells. Interactions between HLA-I and the integrin β4 subunit may contribute to transplant vasculopathy and so represent a potential target for therapies to limit transplant rejection.

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