Editors' ChoiceNetwork Analyses

DNA Damage Pathways Revealed

Science Signaling  07 Dec 2010:
Vol. 3, Issue 151, pp. ec376
DOI: 10.1126/scisignal.3151ec376

Despite the dynamic nature of cellular responses, the genetic networks that govern these responses have been mapped primarily as static snapshots. Bandyopadhyay et al. (see the Perspective by Friedman and Schuldiner) report a comparison of large genetic interactomes measured among all yeast kinases, phosphatases, and transcription factors, as the cell responded to DNA damage. The interactomes revealed were highly dynamic structures that changed dramatically with changing conditions. These dynamic interactions reveal genetic relationships that can be more effective than classical “static” interactions (for example, synthetic lethals and epistasis maps) in identifying pathways of interest.

S. Bandyopadhyay, M. Mehta, D. Kuo, M.-K. Sung, R. Chuang, E. J. Jaehnig, B. Bodenmiller, K. Licon, W. Copeland, M. Shales, D. Fiedler, J. Dutkowski, A. Guénolé, H. van Attikum, K. M. Shokat, R. D. Kolodner, W.-K. Huh, R. Aebersold, M.-C. Keogh, N. J. Krogan, T. Ideker, Rewiring of genetic networks in response to DNA damage. Science 330, 1385–1389 (2010). [Abstract] [Full Text]

N. Friedman, M. Schuldiner, The DNA damage road map. Science 330, 1327–1328 (2010). [Summary] [Full Text]