PerspectiveCell Biology

Myc-Nick: The Force Behind c-Myc

See allHide authors and affiliations

Sci. Signal.  14 Dec 2010:
Vol. 3, Issue 152, pp. pe49
DOI: 10.1126/scisignal.3152pe49

You are currently viewing the abstract.

View Full Text


In the field of molecular oncology, the Myc basic helix-loop-helix family of transcription factors has been extensively studied. The Myc proto-oncogene c-Myc binds DNA, activates or represses gene transcription, and consequently affects cellular proliferation. However, emerging evidence presents the existence of c-Myc variants that lack transcriptional activity. A cytoplasmic variant of c-Myc called “Myc-nick,” which arises from calpain-mediated cleavage of c-Myc, assists in stable microtubule assembly. Furthermore, Myc-nick promotes MyoD-mediated myogenic differentiation, thus antagonizing its precursor. These results provide exciting new opportunities in formulating molecular approaches for treatment of cancer and in our understanding of cell differentiation.

View Full Text