Exiting the Birthplace

Science Signaling  04 Jan 2011:
Vol. 4, Issue 154, pp. ec5
DOI: 10.1126/scisignal.4154ec5

In the developing mammalian brain, new neurons are not always born where they are needed. In order for immature neurons of the mouse cerebellum to leave their birthplace in the germinal zone and find their functional niche in the brain, the neurons need to migrate. Famulski et al. (see the Perspective by Métin and Luccardini) now show that ubiquitin-mediated protein degradation regulates development of specific cell adhesions that the neurons need in order to exit their birthplace en route to their final functional location.

J. K. Famulski, N. Trivedi, D. Howell, Y. Yang, Y. Tong, R. Gilbertson, D. J. Solecki, Siah regulation of Pard3A controls neuronal cell adhesion during germinal zone exit. Science 330, 1834–1838 (2010). [Abstract] [Full Text]

C. Métin, C. Luccardini, Ubiquitination inhibits neuronal exit. Science 330, 1754–1755 (2010). [Abstract] [Full Text]